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Takeshi Iwatsubo Selected Research

alpha-Synuclein

11/2010Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.
3/2009Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease.
10/2008A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans.
9/2008Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
4/2008Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.
4/2008Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.
4/2008Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.
3/2008Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages.
1/2008Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
11/2007Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
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Takeshi Iwatsubo Research Topics

Disease

101Alzheimer Disease (Alzheimer's Disease)
05/2022 - 04/2002
38Parkinson Disease (Parkinson's Disease)
09/2021 - 05/2002
24Dementia (Dementias)
05/2022 - 05/2002
19Amyloid Plaque
12/2020 - 04/2002
17Neurodegenerative Diseases (Neurodegenerative Disease)
11/2021 - 02/2002
17Synucleinopathies
03/2012 - 02/2002
11Cognitive Dysfunction
01/2022 - 11/2002
10Multiple System Atrophy
10/2007 - 05/2002
6Tauopathies
05/2022 - 08/2003
4Frontotemporal Dementia (Semantic Dementia)
11/2021 - 04/2004
4Neoplasms (Cancer)
01/2014 - 06/2004
3Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
05/2022 - 04/2002
3Parkinsonian Disorders (Parkinsonism)
05/2022 - 04/2004
3Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
01/2022 - 04/2006
3Sarcoma (Soft Tissue Sarcoma)
01/2022 - 01/2018
3Down Syndrome (Down's Syndrome)
10/2018 - 07/2004
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2018 - 04/2015
3Atrophy
01/2017 - 11/2008
3Lewy Body Disease (Lewy Body Dementia)
11/2007 - 08/2003
2Insulin Resistance
11/2021 - 12/2019
2TDP-43 Proteinopathies
11/2021 - 11/2013
2COVID-19
10/2021 - 09/2021
2Gliosis
12/2020 - 01/2014
2Disease Progression
01/2019 - 01/2019
2Crohn Disease (Crohn's Disease)
01/2018 - 01/2016
2Infections
07/2013 - 10/2004
1Neuroinflammatory Diseases
12/2021
1Type 2 Diabetes Mellitus (MODY)
11/2021
1Bell Palsy (Bell's Palsy)
10/2021
1Paralysis (Palsy)
10/2021
1Epilepsy (Aura)
09/2021
1Chronic Disease (Chronic Diseases)
09/2021
1Migraine Disorders (Migraine)
09/2021
1Inflammation (Inflammations)
12/2019
1Carotid Stenosis (Carotid Artery Stenosis)
01/2019
1Proteostasis Deficiencies
01/2019

Drug/Important Bio-Agent (IBA)

54Amyloid (Amyloid Fibrils)IBA
05/2022 - 04/2002
36alpha-SynucleinIBA
11/2010 - 02/2002
32Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2002
29Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2016 - 04/2002
25Peptides (Polypeptides)IBA
12/2020 - 04/2002
23Amyloid beta-PeptidesIBA
01/2014 - 11/2002
12Biomarkers (Surrogate Marker)IBA
01/2022 - 11/2002
12Phosphotransferases (Kinase)IBA
11/2020 - 11/2006
11Leucine (L-Leucine)FDA Link
11/2020 - 11/2006
8Apolipoproteins E (ApoE)IBA
01/2020 - 01/2006
8Peptide Hydrolases (Proteases)FDA Link
01/2016 - 09/2004
8PresenilinsIBA
01/2014 - 04/2002
7Presenilin-1IBA
01/2016 - 11/2002
6Pharmaceutical PreparationsIBA
05/2022 - 12/2010
6AntibodiesIBA
09/2009 - 12/2002
5Flavin-Adenine Dinucleotide (FAD)IBA
03/2010 - 03/2003
4Donepezil (Aricept)FDA LinkGeneric
01/2022 - 01/2021
4ApolipoproteinsIBA
01/2020 - 01/2006
4CalciumIBA
01/2019 - 06/2008
4sarkosylIBA
02/2016 - 04/2002
4CollagenIBA
01/2014 - 04/2002
4SynucleinsIBA
03/2012 - 04/2008
3LipidsIBA
03/2022 - 05/2005
3Protein Kinases (Protein Kinase)IBA
11/2020 - 02/2007
3N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA
01/2015 - 07/2013
3Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA
10/2009 - 02/2007
3Serine (L-Serine)FDA Link
03/2009 - 10/2003
2CytokinesIBA
12/2021 - 05/2004
2Insulin (Novolin)FDA Link
11/2021 - 12/2019
2thioflavin TIBA
12/2020 - 07/2004
2Trans-Activators (Trans-Acting Factor)IBA
01/2019 - 04/2015
2CholesterolIBA
10/2018 - 05/2005
2tau Proteins (tau Protein)IBA
11/2017 - 03/2005
2GTP-Binding Proteins (G-Protein)IBA
01/2013 - 02/2007
2Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA
03/2010 - 06/2008
2Membrane Proteins (Integral Membrane Proteins)IBA
10/2009 - 04/2002
2Codon (Codons)IBA
11/2007 - 11/2002
2Gamma Secretase Inhibitors and ModulatorsIBA
06/2006 - 06/2004
2Monoclonal AntibodiesIBA
04/2006 - 04/2002
2Protein Isoforms (Isoforms)IBA
04/2006 - 04/2004
2Endopeptidase K (Proteinase K)IBA
11/2002 - 05/2002
1Microfilament Proteins (Actin Binding Proteins)IBA
05/2022
1FilaminsIBA
05/2022
1Antipsychotic Agents (Antipsychotics)IBA
05/2022
1BenzodiazepinesIBA
05/2022
1benzamideIBA
05/2022
1Anticonvulsants (Antiepileptic Drugs)IBA
05/2022
1Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA
05/2022
1phenothiazineIBA
05/2022
1Monomeric GTP-Binding ProteinsIBA
01/2022
1RNA-Binding Proteins (RNA-Binding Protein)IBA
01/2022
1Casein Kinases (Casein Kinase)IBA
01/2022
1Antisense OligonucleotidesIBA
12/2021
1Insulin ReceptorIBA
11/2021
1Long Noncoding RNAIBA
11/2021
1mRNA VaccinesIBA
10/2021
1Influenza Vaccines (Influenza Vaccine)FDA Link
10/2021
12019-nCoV Vaccine mRNA-1273IBA
10/2021
1BNT162 VaccineIBA
10/2021
1rab GTP-Binding ProteinsIBA
11/2020
1Fatty Acids (Saturated Fatty Acids)IBA
01/2019

Therapy/Procedure

13Therapeutics
01/2022 - 06/2004
2Activities of Daily Living (ADL)
01/2014 - 07/2013
1Ambulatory Care (Outpatient Care)
09/2021